Ketotifen Fumarate – Antihistamine & Mast Cell Stabilizer
Ketotifen Fumarate is a second‑generation H1‑receptor antagonist with potent mast cell stabilizing properties. Widely used in research, it inhibits the release of histamine and other inflammatory mediators (e.g., leukotrienes, PAF), making it valuable for studying allergic responses, asthma, and atopic conditions. Additionally, Ketotifen exhibits weak serotonin antagonism and is investigated for its role in preventing beta‑2 receptor downregulation in cellular models.
Key Research Applications:
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Allergic rhinitis and conjunctivitis models
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Asthma and bronchial hyperreactivity studies
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Mast cell‑mediated inflammation
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Receptor sensitivity modulation



