RU-58841 – Topical Antiandrogen for Androgenetic Alopecia
RU-58841 is a non‑steroidal androgen receptor antagonist developed for topical application in hair loss research. It binds competitively to androgen receptors in the scalp, inhibiting the effects of dihydrotestosterone (DHT) and testosterone on hair follicles. Unlike systemic antiandrogens, RU-58841 is designed to act locally with minimal systemic absorption, making it a promising candidate for studying androgenetic alopecia (male/female pattern baldness) , hair thinning, and androgen‑related hair disorders. Research suggests it may preserve hair density without the sexual side effects associated with oral treatments.
Key Research Applications:
-
Androgenetic alopecia models
-
Topical antiandrogen delivery studies
-
Hair follicle protection against DHT


